Author post: VSEAMS: A pipeline for variant set enrichment analysis using summary GWAS data identifies IKZF3, BATF and ESRRA as key transcription factors in type 1 diabetes
Haldane’s Sieve: Olly Burren writes about our
latest preprint on arXiv, a method for relating GWAS summary statistics to functionally defined gene sets which doesn’t require access to raw genotyping data.
SNP arrays are a great way of cheaply genotyping a large number of individuals for genome-wide association studies.
This is what you expect a typical SNP to look like:
There are three clearly distinguishable clusters representing the three possible genotypes at that locus (
TT, TC and CC).
But some SNPs look like this:
What is going on here?
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Papers and tagged CNV, HLA-Bw4, ImmunoChip, imputation, KIR, KIR2DL3, KIR2DL5, KIR2DS1, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DS1, qPCR, T1D on . April 12, 2014